Monthly Archives: June 2017

, 1997). Noonan et al. (2010) report just such an effect (Figure 4A). The lesions were made in the medial orbitofrontal cortex in macaques, in the region Mackey and Petrides (2010) argue corresponds to the human reward-related vmPFC/mOFC region (Figure 2B). The vmPFC/mOFC … Continue reading →

e., the rate of evidence accumulation) is allowed to vary across trials. Varying drift rate randomly across successive trials allows different admixtures of trials with high and low drift rates to drive correct and incorrect choices, Compound C leading to … Continue reading →

The percentage of total frames exhibiting motion versus pausing was calculated from the pooled image frames of multiple animals (n > 10) of each genotype. For body bending curvature change overtime, young adult C. elegans was recorded at 40× magnification. Midline … Continue reading →

Genotypic procedures are described in the supplemental experimental procedures. All animal treatments were done in accordance with the regulations and policies of the Johns Hopkins Animal Care and Use Committee. Antibodies were used at the following dilutions: anti-IIH6 (1:100, Millipore), … Continue reading →

We then aligned the confocal and two-photon image stacks and determined whether the recorded compartments were axon terminals of bipolar cells, processes of starburst cells, or dendrites of ON DS cells (Figures 3A, 3B, and S3). Starburst processes could be … Continue reading →

, 1995; Rosenberg et al., 2009; Hallmayer et al., 2011). Yet, due to the complexities of both ASD genetic architecture and brain-behavior relationships, great challenges remain in delineating how ASD risk genes shape the circuits underlying social behavior. Brain imaging studies have … Continue reading →

Cells were defined as border cells if (1) the spatial information content in the recorded selleck screening library data was higher than the corresponding 95th percentile in the shuffled data, and (2) the border score from the recorded data was … Continue reading →

To investigate whether M1 activity caused the 6–14 Hz activity or simply coordinated ongoing activity, we also calculated STPC in the DS surrounding application of ICMS to M1 (Figure 5C) and found that STPC was significantly enhanced after M1 ICMS (p < 0.001, … Continue reading →

The incorporation of G12 primers into RT-PCR testing kits since 2000 has helped establish prevalence data for G12 strains in India. Continued surveillance will be necessary to document an expected click here trend of expansion and reassortment in coming years. … Continue reading →

Compared to solid SiNPs, MSNs have higher loading capacity for their larger specific surface area, and better performance in delivery RG7204 clinical trial and controlled release due to the tunable hollow and mesoporous structure. In addition, MSNs can be degraded … Continue reading →