RGT with PEG-IFN+RBV may be a low-cost option in resource-limited

RGT with PEG-IFN+RBV may be a low-cost option in resource-limited regions. Our aim was to systematically and quantitatively assess treatment response beta-catenin phosphorylation and on-treatment predictors of SVR in HCV-4 patients treated with PEG IFN+RBV. Methods: In November 2013, we conducted a comprehensive literature search in two databases (EMBASE and Medline) and four

major scientific conferences (AASLD, APASL, DDW, and EASL in 2012-2013). We included original studies with ≥25 treatment-naïve HCV-4 patients treated with PEG IFN+RBV for 48 weeks. We used random-effects model to produce pooled event rates for primary and sub-group analyses. Study heterogeneity was defined as Cochrane Q-statistic with p ≤ 0.05 and I2-statistic ≥ 50%. Results: Our primary

analysis included a total of 11,102 patients from 51 studies. Pooled SVR rate was 53% (95% CI: 50-55%) (Table 1). Pooled RVR (undetectable HCV RNA at 4 weeks of treatment) rate was 35% (95% CI: 27-44%) and EVR (undetectable HCV RNA at 12 weeks of treatment) rate was 65% (95% CI: 54-75%). Rates of SVR were 94% (95% CI: 85-97%) in patients who reached RVR and 74% (95% CI: 66-81%) in Pexidartinib patients who reached EVR. In contrast, SVR was 35% (95% CI: 18-57%) in patients who did not achieve RVR and 11% (95% CI: 3-33%) in patients who did not achieve EVR. Higher SVR was significantly associated with achieving RVR, OR 42.7 (95% CI: 3.15-579.20, p=0.005) or EVR, OR 34.69 (95% CI: 5.27-228.26, p<0.005). Conclusions: HCV-4 patients can expect SVR ∼50% with 48-weeks of PEG IFN+RBV. RVR is a good positive predictor of SVR (>90% in RVR+ patients), while EVR is a good negative predictor of SVR (∼10% in EVR- patients). The absence of EVR is a good stopping rule in HCV-4 patients treated with PEG-IFN+RBV for 48 weeks. Pooled event rates and odds ratios for treatment predictors in HCV-4 patients with PEG IFN+RBV Disclosures: Mindie H. Nguyen – Advisory Committees or Review Panels: Bristol-Myers Squibb, Bayer AG,

上海皓元 Gilead, Novartis, Onyx; Consulting: Gilead Sciences, Inc.; Grant/Research Support: Gilead Sciences, Inc., Bristol-Myers Squibb, Novartis Pharmaceuticals, Roche Pharma AG, Idenix, Hologic, ISIS The following people have nothing to disclose: Brittany E. Yee, Nghia H. Nguyen, Bing Zhang, Philip Vutien, Carrie R. Wong, Glen A. Lutchman Background and Aims: A triple combination therapy of Sime-previr (SMV), pegylated-interferon and ribavirin (PR) was launched to clinical practice in Japan on December of 2013, ahead of the rest of the world. This regimen is recommended for genotype 1 hepatitis C in AASLD, EASL and WHO guidelines based the data of phase 3 trials. However, its efficacy should be evaluated in real-life experiences.

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