112). In lateral sites, musical sounds (both NAT and ROT) elicited a larger N1 over the right than over the left hemisphere sites (hemisphere by sound type, F1,34 = 7.376, P = 0.01, ηp2 = 0.178; hemisphere, F1,34 = 6.094, P = 0.019, ηp2 = 0.152) while the N1 amplitude elicited by vocal sounds was similar across the two hemispheres. Lastly, the group by hemisphere by site interaction was marginally significant (F3,102 = 3.172, P = 0.055, ηp2 = 0.085) due to the fact
that the two groups differed across a larger array of electrodes over the right as compared with the left hemisphere. Musicians had a significantly larger N1 peak amplitude than non-musicians at frontal, fronto-temporal and temporal–parietal sites (F1,34 = 4.294–5.953, P = 0.02–0.046, ηp2 = 0.112-0.149) Selumetinib molecular weight over the right hemisphere, but only at frontal sites (F1,34 = 7.793, P < 0.01, ηp2 = 0.186) over the left. The two groups did not differ in N1 peak latency. There was also no group by naturalness interaction (midline, F1,34 < 1; mid-lateral, F1,34 < 1; lateral, F1,34 = 2.259, P = 0.142). The analysis yielded only one significant finding – namely, deviant sounds elicited N1 with a longer peak latency (midline, F1,34 = 55.942, P < 0.001, ηp2 = 0.622; mid-lateral, F1,34 = 52.275, P < 0.001, ηp2 = 0.606; lateral, F1,34 = 23.724, P < 0.001, ηp2 = 0.411). In summary, musicians had a significantly larger
N1 peak amplitude KU-57788 solubility dmso to all sound and stimulus types in both Astemizole the NAT and the ROT conditions. At lateral sites, this difference was present over a larger array of electrodes over the right as compared with the left hemisphere. The two groups did not differ in the peak latency of N1. Musicians and non-musicians did not differ in the mean amplitude of the P3a component. Additionally, the factor of group did not interact with other factors. The amplitude of P3a was larger to NAT as compared to ROT sounds (F1,34 = 25.833, P < 0.001, ηp2 = 0.432). This difference was probably due to the reduced timbre distinctiveness between standards and deviants in the ROT condition. The P3b analysis yielded no group effect and no interactions between group and other factors. The
only significant finding was that its mean amplitude was significantly larger to NAT as compared to ROT sounds (midline, F1,34 = 9.892, P < 0.01, ηp2 = 0.225; mid-lateral, F1,34 = 12.248, P < 0.01, ηp2 = 0.265; lateral, F1,34 = 11.458, P < 0.01, ηp2 = 0.252). This finding is parallel to that in the P3a analysis and is likewise probably due to the reduced timbre distinctiveness between standards and deviants in the ROT condition. In summary, musicians and non-musicians did not differ in the mean amplitude of either P3a or P3b components. Musicians tended to have a marginally larger mean amplitude of RON compared with non-musicians over mid-lateral and lateral sites (mid-lateral, F1,34 = 3.211, P = 0.082, ηp2 = 0.086; lateral, F1,34 = 3.676, P = 0.064, ηp2 = 0.
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