[16] There is, however, a single publication suggesting that the

[16] There is, however, a single publication suggesting that the AIIA losartan may be superior to angiotensin-converting-enzyme inhibitors (ACEIs) in regard to cognitive function[17] and a recent large study of eprosartan demonstrated improved cognition in parallel with decreased blood pressure.[18] It is also worthy of note that in the study of cognition, adherence and Ku 0059436 blood pressure by Vinyoles et al.,[3] cited above, lack of cognitive impairment was associated with better

adherence to medication, better blood-pressure control, and use of monotherapy, the most common of which was AIIA (28.6%). We also have data from young, healthy normotensive volunteers showing that a single dose of the AIIA losartan evoked some modest, but statistically significant, improvement in aspects of scopolamine-impaired cognition, notably prospective memory.[19] Prospective memory is that aspect of memory concerning remembering to do something in the future, for example remembering to take a letter for posting

when next going shopping. Prospective memory may be of particular relevance when considering find more cognitive impairment in the elderly. The aim of this study was to assess the literature concerning the relationship between hypertension, cognitive impairment and the potential benefits of antihypertensive therapy. The ISI Web of Knowledge database was searched using the keywords antihypertensive, hypertension or blood pressure separately combined with cognition, dementia or Alzheimer’s disease. Publications identified were assessed by the author and those relating to animal- or cell-based

studies were excluded, as were editorials, conference abstracts and case reports. Only publications in English or with an English-language abstract were considered further. For the nine searches conducted, the average number of publications Casein kinase 1 identified for each was 1352, ranging from 185 for ‘antihypertensive’ combined with ‘Alzheimer’s disease’ to 2930 for ‘hypertension’ and ‘dementia’. The earliest identified reference was from 1952.[20] Of the publications identified, 9.9% had been published in 2009, indicating the acceleration of interest in this topic. Because of the large number of critical reviews published recently, it was decided to focus on English-language publications from 2009 or later; 18 original publications meeting the criteria listed above were identified (see Figure 1). Six systematic literature reviews of the subject were published in 2009. Purnell et al.[21] reviewed papers up until 2007 and concluded that hypertension was not associated with Alzheimer’s disease and McGuiness et al.[22] concluded that antihypertensive therapy late in life had no effect on the incidence of dementia, based on a review of papers up until early 2008. Kennelly et al.

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