26, P = 0.009) and negative correlation of IVRTm (r = −0.22, P = 0.02) were determined. There is a significant relationship between AS and left ventricular diastolic dysfunction in patients with SS in this study. The parameters of aortic elasticity measured by 2D echocardiographic methods can be beneficial in predicting early cardiovascular risk in SS. “
“In this issue of the International Journal of Rheumatic Diseases, several papers focus on new investigations or new recommendations for Asian systemic lupus erythematosus (SLE). Previous work has consistently LY2109761 clinical trial shown that Asian patients have higher rates of renal involvement compared to Caucasian patients[1,
2] and that lupus nephritis is a significant cause of chronic renal failure.[3] Asian SLE patients may also have poorer outcomes Omipalisib price and more severe renal involvement.[4]
As such, one of the papers in this volume focuses on Asian lupus nephritis management guidelines. Led by a panel of 15 nephrologists and rheumatologists from different Asian regions with extensive interest and experience in lupus nephritis, the Asian Lupus Nephritis Network (ALNN) steering group provides a summary of the current literature regarding lupus nephritis treatment options in Asian patients and provides expert consensus views about Asian lupus nephritis treatment.[5] After summarizing the current lupus nephritis recommendations from the Kidney Disease Improving Global Outcomes (KDIGO), American College of Rheumatology (ACR), and the joint European League against Rheumatism and European Renal Association-European Dialysis and Transplant Association (EULAR/ERA-EDTA),
ALNN provides some summary suggestions for treatment of lupus nephritis in Asian patients based upon published Asian studies and expert opinion. However, these ALNN guidelines are based upon data garnered from predominantly Chinese patients. Asian lupus nephritis patients from the middle east and south Asian countries, including the subcontinent, Thiamet G need to be studied as they may require different treatment options and guidelines due to differences in disease presentation and progression. Strong conclusions cannot be drawn from the two papers on lupus nephritis from Iran in this issue,[6, 7] due in part to small sample sizes and the retrospective nature of their studies; however, high prevalence of renal failure in both the cohorts are noteworthy. As in all racial groups, treatment is guided by histological and clinical nephritis severity, as well as by extra-renal lupus manifestations.[5] Mild to moderate renal disease, including patients with Class II mesangial proliferative, may be treated with moderate disease corticosteroids with or without an additional immunosuppressive agent as a steroid-sparing agent.
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