6% 74.6% 36.3% False-negative rate 2.1% 2.0% 2.4% LRa-positive test 2.1 1.3 2.7 LRa-negative test 0.04 0.08 0.04 aLikelihood ratio Overall, the FirstSign Malaria Pf has shown a sensitivity as high as 97.9% (95% CI 96.3–98.8), but a this website low specificity of 53.4% (95% CI 49.1–57.7). The specificity was significantly lower during the high transmission YH25448 research buy season at 25.4% (95% CI 20.5–31.0) compared to 63.7% (95% CI 57.6–69.4%) at the low transmission season (Fig. 1). Fig. 1 Diagnostic accuracy of the RDT according to malaria transmission seasons
The NPV was 95.4% (95% CI 93.2–96.9) and PPV was 71.7% (95% CI 67.7–75.4). The NPV was significantly higher during the low transmission season at 98.2% (95% CI 95.7–99.3) than compared to the 80.0% (95% CI 74.7–84.4) at the high transmission season. During the high transmission season, the false-positivity rate was twice that observed during the low transmission (74.6% vs. 36.3%). The likelihood ratio for positive tests was two times higher during the low transmission season compared to the high transmission season (2.7 vs. 1.3). For negative test, the likelihood ratio was two times lower during the low transmission season (0.04 vs. 0.08). From the 385 positives tests, 109 (28.3%) were false positive. A total of six tests were false negative out of the 131 negative FirstSign Malaria Pf tests. From
these six subjects, one subject had a low parasite density (95 parasites/μL). The parasite count ranged from 3,347 to 185,020 parasites/μL Selleck PX-478 for the five remaining subjects. All of them had coincidental acute respiratory tract infection and had received cotrimoxazole. Fever was resolved when they were seen 3 until and 7 days after the onset of treatment. Stratification by age and P. falciparum parasite density showed that the lowest sensitivity and specificity were recorded in children aged 48–59 months harboring less than 500 asexual parasites/μL
[respectively, 85.7% and 43.3% (33.0–54.2%)] (Table 3). Table 3 Diagnostic accuracy of rapid diagnostic test (RDT) by parasite density and age group (any malaria transmission season) Age group (months) Parasite count RDT results Sensitivity (%) Specificity N Positive Negative <500 38 17 21 100 0–11 500–4,999 6 6 0 100 5,000–9,999 3 3 0 100 60% (48.8–70.3) ≥10,000 29 28 1 96.6 Overall 76 54 22 97.6 <500 69 31 38 100 12–23 500–4,999 17 17 0 100 5,000–9,999 5 5 0 100 60.3% (52.4–67.7) ≥10,000 61 61 0 100 Overall 152 114 38 100 <500 64 36 28 100 24–35 500–4,999 9 9 0 100 5,000–9,999 5 5 0 100 46.7% (37.8–55.8) ≥10,000 37 36 1 97.3 Overall 115 86 29 98.2 <500 47 23 24 100 36–47 500–4,999 6 6 0 100 5,000–9,999 2 2 0 100 55.8% (45.2–65.9) ≥10,000 29 29 0 100 Overall 84 60 24 97.6 <500 37 23 14 85.7 48–59 500–4,999 12 11 1 91.
Related posts:
- Allografts
from HBsAg positive donors were even used in r - 22 Due to a higher negative charge on cell surface, the interacti
- The positive and unfavorable controls were Inhibitors,Modulators,
- In the case of gram-positive bacteria, it should be analyzed more
- In summary, the dilemma of positive scintigraphic evidence of col