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“Introduction Several authorities have
GSK1120212 called attention to the morbidity, mortality and excess health costs associated with antibiotic-resistant pathogens and the need to prioritize development of antibacterial agents that can safely and effectively treat these pathogens [1–4]. Ceftaroline fosamil is a novel cephalosporin, with bactericidal in vitro activity against pathogens associated with licensed indications, including resistant organisms, such as methicillin-resistant Staphylococcus aureus (MRSA), multidrug-resistant Streptococcus
pneumoniae (MDRSP) and penicillin-resistant S. pneumoniae (PRSP) [5]. Supported by preclinical in vitro and animal model studies [6–10] and clinical trials [11–15], ceftaroline fosamil (Teflaro™; Forest Laboratories, Inc., New York, USA) was approved by the United States Food and Drug Administration (FDA) in October 2010 for the treatment of adults with community-acquired bacterial pneumonia (CABP) and acute bacterial skin and skin structure infections (ABSSSI) caused by susceptible organisms Sitaxentan [5]. Ceftaroline fosamil is the newest of only three systemic antibiotics approved for human use by the FDA over the past 5 years and the only one of these approved for the treatment of CABP. Similarly, the European Commission granted marketing authorization for ceftaroline fosamil (Zinforo™; AstraZeneca, Södertälje, Sweden) in August 2012 for the treatment of community-acquired pneumonia and complicated skin and soft tissue infections following favorable opinion from the Committee for Medicinal Products for Human Use [16]. This report reviews the recent literature published on ceftaroline fosamil, including the pivotal clinical trials that led to its approval, and highlights areas that need to be addressed in the future.
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