Urogenital sinus, and it U Eren genital warts from drafts and the prostate U Eren genital differentiation. However, the activity t R 5 is not in the Wolffian duct at the Dihydrofolate Reductase review time of the epididymis, vas deferens, seminal vesicle and differentiation. For example, T and DHT have r The selective m Nnliche sexual differentiation may need during the embryogenesis.
TmediatesWolffian ductal differentiation, w While DHT mediatesmale U Eren genitals and differentiation of the prostate. 5 R2 deficiency is caused by decreased synthesis of DHT by mutations in the gene 5-reductase-2. At least 50 mutations have been described and it is autosomalrecessive in most patients. 5 R2 deficiency leads to a 46, XY St Changes of sexual development.
Affected M Men with normal male pattern reproductive internal structures are born, but their U Eren genitals Resemble those of women, hot t, genitals. These people have a small penis, the clitoris, labioscrotaux fusion, is a urogenital sinus and in which there are two separate Openings of the vagina and urethral Hre Is similar. The vagina is short and end blindly. The testicles are either in the lips or the groin canals or intraabdominal le. Vasa blind ending Scheidengew Lbe. Hypoplastic prostate, is not palpable on digital rectal examination and found that rudimentary on transrectal ultrasound and MRI r. Prostate volumes were approximately matched for age s normal controls. Prostate biopsy revealed, connective tissue, smooth muscle, and no identifiable epithelial tissue, suggesting atrophic epithelium or lack of epithelial differentiation.
Plasma PSA is low or undetectable in these patients. The administration of DHT in the prostate-mag Phase control. Neither BPH nor CAP has been reported in these patients. In puberty T, they are partly the virilization U Eren sexual organs, although their secondary Ren hair sex characteristics are rare and they develop male pattern baldness and acne less, despite normal production of sebum. They go through an increase in muscle mass, phallic growth, the development of the male habit, and consolidation of the administration of DHT, but is reversed by treatment 3 androstanediol.
High normal or increased hte concentrations of plasma T, low normal to decreased plasma DHT, T to DHT compared to the baseline and after hCG stimulation, the normal metabolic clearance increased ht T and DHT: The biochemical characteristics of this syndrome lower levels of urinary metabolites C19 and C21 5 reduces stero of, metabolites in urine increased 05:05 ratio ratios, decreased plasma and urinary androstanediol 3-glucuronide, a metabolite of DHT, increased ht plasma levels of LH and / or FSH. Ph Genotype, development and reproductive function in female human 5-R2 deficiency are not affected. 10.2. TUBA attributed BPE. BPE registered Not significant morbidity t due to secondary urethral Lead obstruction and detrusor dysfunction. Histological evidence of BPH in 50% of the men between the ages of 50 and 90% of the men found at the age of 80. The development of BPH is dependent Ngig of androgens, and BPH at M Nnern not occur before puberty Castrated t. 5 R isoenzymes play an R In the development of BPH Important Since DHT is the primary androgen in the prostate. Patients with DHT production has fallen by 5 R2 CHALLENGE
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