Alternatively, the inhibition of c-kit, which is expressed especially in the interstitial cells of Cajal pacemaker discussed. Diarrhea can be easily managed through cooperation antidiarrheal medication in most symptomatic patients. Fluid retention and Kardiotoxizit t fl uid retention and easy Are the GSK1059615 other h INDICATIVE toxicity th Associated with imatinib dose that. Approximately 50 70 of the patients For Periorbital edema non-specific treatment in most cases Cases necessary. Fl uid severe generalized retention is much less common but potentially t Dliche event was reported in less than 1 in the chronic phase, but are available in 3 and 6 patients in accelerated phase and blast crisis. It can function as lungs Said, pleural or pericardial effusion, ascites, hydrops, joint effusion and brain Sentieren the pr.
Live events out Ants this syndrome fl uid retention SP600125 and death from the brain Were attributed to. The mechanism underlying such widespread retention by imatinib and fl uid Caused the m May receive not compatible. A m Possible explanation Tion k Nnte Be inhibition of the goals for the integrity of t Capillaries with imatinib. Mice With homozygous deletions of PDGF B or PDGFR defective genes blood vessels S and Deme and abl knockout M Nozzles also doubly bad Deme what r a These tyrosine kinases. In addition, a monoclonal antique PDGFR body ? ?? ? ?? ntibody as anticancer agents in early clinical phase 8 patients had cancer Born fl uid retention cases in 7 F Used.
Another mechanism, fl uid retention in some patients is the development of severe heart failure, presumably because of the toxic cardiomyopathy YEARS Abl ring, which has been recently described. However, the evidence of the clinical significance bearing imatinib-induced Kardiotoxizit t still low. There is a need for further studies to Kardiotoxizit t in patients to assess the substance, taking into account the weight Hlten dosages of medications, existing heart disease, and the use of other cardiotoxic medicaments. These rated Atallah et al all serious adverse events w Imatinib reported during various tests. Among the treated patients with CML with imatinib, 1276, 22 patients were identifies as having CHF by the Framingham criteria. Patients who developed CHF compared with significantly cant patients with no such symptoms I and 82 patients with CHF had a history of predisposition to heart disease.
This reconstruction rmed some of the risk factors previously recognized for imatinib induces retention fl uid. In fact, the incidence of CHF was by age group almost identical to that in the general Bev Lkerung the Framingham study. The H half Of patients who developed CHF continued imatinib therapy with dose adjustments and management of their symptoms My CHF without further complications. They should the patients closely for the presence of peripheral demes, Rapid weight gain and other clinical symptoms of cardiac dysfunction m Monitoring possible. However, a systematic echocardiographic monitoring is not in asymptomatic patients were treated with imatinib apparently are not specified. Counseling and appropriate Ma took Ventricular assist 
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