In addition, colonoscopies are technically more difficult to perform in women who have undergone gynecologic
(pelvic) surgeries. Both previous gynecologic surgery and previous hysterectomy are independent predictors of difficulty of intubation in unsedated female patients.9 It is not known whether WEC would facilitate the performance of colonoscopy in unsedated female patients with a history of pelvic surgery. We report a prospective, randomized, controlled trial (RCT) that was designed to investigate whether, compared with conventional air colonoscopy (AC), WEC could increase cecal intubation rates in Asian (Chinese) patients with prior abdominal or pelvic surgery. This prospective, patient-blinded RCT, approved by the local institutional review board (ClinicalTrials.govNCT01485133) BGB324 chemical structure was conducted at the Endoscopic Center of Xijing Hospital, China. Written informed consent was obtained from all the patients. The ratio of unsedated to sedated colonoscopy is about 3:1, and both sedated and unsedated colonoscopy are routine at our center. From November 2011 to July 2012, outpatients GSK 3 inhibitor who underwent unsedated colonoscopy were invited to participate. Patients with a history
of abdominal or pelvic surgery were enrolled. Exclusion criteria included any of the following: aged <18 years or >80 years; current pregnancy; history of colon resection; severe colon stricture or obstructing tumor; hemodynamic instability; and inability to provide informed consent. Patients who met the inclusion criteria
were randomly assigned to the WEC or AC group by using Interleukin-3 receptor computer-generated random numbers immediately before the examination. The randomization list was not accessible to the endoscopists or assistants. The preparation method was reported with an acceptable cleansing rate and tolerance.10 All patients consumed a regular meal for lunch and clear liquids for dinner the day before the colonoscopy. They drank two sachets of polyethylene glycol 4000 electrolytes powder (WanHe Pharmaceutical Co, Shenzhen, China) dissolved in 2 L of water between 4:00 am and 5:00 am within 2 hours of the colonoscopy on the same day of colonoscopy. Patients were encouraged to drink more clear liquids after purgatives for adequate hydration before colonoscopy. Patient blinding involved colonoscopists not informing the patients of the methods, the set-up (colonoscope, water pump, and other equipment) was the same for both WEC and AC, and the display screen was placed over the head of the patients so they could not see the endoscopic images. All colonoscopies were performed from 9:00 am to 1:00 pm by two experienced colonoscopists (Y.L.P. or L.H.Z.). Before the start of the study, both had performed >2000 ACs and 50 WECs (with 100% cecal intubation rate in the last 30). The variable-stiffness colonoscope (CF-Q260; Olympus, Beijing) was used. An assistant explained to the patients the pain scores (degree of abdominal pain) to be used.
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