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apoptosis, necrosis and reactive oxygen damage. Oncogene 1999,18(54):7719–7730.CrossRef 70. Matés JM, Segura JA, Alonso FJ, Márquez J: Intracellular redox status and oxidative stress: implications for cell proliferation, apoptosis, and carcinogenesis. Arch Toxicol 2008,82(5):273–299.CrossRef 71. Chuang SM, Lee YH, Liang RY, Roam GD, Zeng ZM, Tu HF, Wang SK, Chueh PJ: Extensive evaluations of the cytotoxic effects of gold nanoparticles. Biochim Biophys Acta 2013,1830(10):4960–4973.CrossRef Competing interests The authors declare that they have no competing interests. Authors’ contributions SG came up with the idea and participated in the design, preparation of AuNPs, and writing of the manuscript. JWH performed characterization of nanoparticles. JHP participated in culturing, cell viability, LDH, and ROS assay. SG and JHK participated in coordination of this study. All authors read and approved the final manuscript.”
“Review Introduction Gene therapy is described as the direct transfer of genetic material to cells or tissues for the treatment of inherited disorders and acquired diseases. The base of this therapeutic method is to introduce a gene encoding a functional protein altering the expression of an endogenous gene or possessing the capacity to cure or prevent the progression of a disease [1–3].
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