Methods: Male Sprague-Dawley rats were randomly allocated to 4 treatment groups (n = 10): water + water, indomethacin (8 mg/kg) + water, indomethacin + Olive Oil (OO) and indomethacin + EO. Rats were gavaged daily with water or oil from days 0–12 (0.5 ml) and water or indomethacin from days 5–12 (0.5 ml). Rats were euthanized on day 12 for intestinal tissue collection. Jejunal
and ileal samples (4 cm) were assessed for neutrophil infiltration indicative of acute inflammation using the colorimetric myeloperoxidase (MPO) assay (450 nm) expressed as units of MPO per gram of tissue (U/g). p < 0.05 was considered significant. Results: Jejunal MPO levels in indomethacin-treated rats were significantly greater compared with normal controls (208 ± 39 U/g and 62 ± 15 U/g, respectively; p < 0.01). Amongst indomethacin-treated groups, both OO (76 ± 21 U/g) and EO (76 ± 23 U/g) significantly NVP-LDE225 nmr reduced levels of acute jejunal inflammation by 28% and 30% respectively, compared with indomethacin controls (p < 0.01). In the ileum, MPO levels were significantly greater in indomethacin-treated rats compared with normal controls (345 ± 40 U/g and 170 ± 29 U/g, respectively; p < 0.01). However, only EO (174 ± 28 U/g; p < 0.05), but not OO (285 ± 45 U/g; p > 0.05), significantly
reduced ileal MPO levels by 50% in indomethacin-treated rats, compared to the indomethacin control. Conclusions: Emu Oil reduced MPO levels Rucaparib mouse in the jejunum and ileum of rats with NSAID-induced enteropathy, indicative of decreased acute inflammation. This further suggests the therapeutic potential of Emu Oil to alleviate gastrointestinal symptoms associated with NSAID usage. AM FERGUSON,1 EG QUINN,1 J ROBERTS,2 C ROGGE,2 TW LEE2 1Department of Nutrition and Dietetics,
ISLHD, Wollongong, Australia, 2Department of Gastroenterology, ISLHD, Wollongong, 上海皓元医药股份有限公司 Australia Introduction: Body composition and dietary behaviour changes occur in patients with IBD and when compared to healthy controls, consume altered macro and micronutrients. Blood tests alone cannot determine nutritional status; instead, several aspects including anthropometry and weight loss, dietary intake and nutrition assessment tools can establish existence of malnutrition. The aim was to examine risk and rates of malnutrition and weight loss in patients with IBD attending an outpatient clinic. Method: The clinic consisted of 2 gastroenterologists, an IBD nurse and a dietitian. All patients were prospectively screened for malnutrition using short nutrition assessment questionnaire (SNAQ) tool1 and referred to the dietitian if deemed at risk. Patients could also self refer or be identified by gastroenterologists to have nutritional concerns. Data collected over 6 months on anthropometry, usual and previous dietary intake and nutrition assessment score using subjective global assessment (SGA) tool2.
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