T T in ARDS BODY MASS INDEX makes a difference Mr. Katsiari1, A. Maguina1, A. Koutsoukou2, C Roussos2, J. Milic Emili2, NG Koulouris3 1ICU, Konstantopoulion H Pital 2ICU general, the H Pital Evangelismos General, 31 Department of Respiratory Medicine, H Pital for Lung Diseases Sotiria, Athens, INTRODUCTION Greece. Nutlin-3 Cancer To determine whether, the body mass index (BMI does not affect the action of three Man Vern recruitment (RM on oxygenation in patients with early ARDS. METHODS. In prospective clinical study, multi-disciplinary in one unit. Ren ICU Twenty-five consecutive patients two groups stratified by their BMI:.
Group A included patients BMY 7378 21102-95-4 with a BMI of 27 kg/m2 (n 11 \, w were during group B, patients with a BMI of 27 kg/m2 C (N14 CLSD min before (pre, immediately (0 and 15 min after three different MR in Feeder lliger order applied 1RM contr pressure ventilation for 1 min at inspiratory pressure 40 cmH2O, PEEP of 5 cm H2O inspiration and expiration date to 1:1, RM 2: two hyper inflations with CPAP cm of 45 H2O and 20 seconds every 1 minute for the lung protective strategy, RM 3: three consecutive months, sigh, reach a tidal volume as to a plateau pressure 45cmH2O RESULTS On the day of the study was oxygen supply in both groups similar, w while a significant difference in the intrinsic PEEP was identified .. (0.90.5 vs 32.9, p0.029, are in Group A and B. The effect of three regional municipalities of the two groups in the table below. Table 1 PaO2/FiO2 (mmHg Group A Group B before the RM 0 min 15 min prior to RM 0 min 15 min 1 15735 20051 16638 12839 190115 12940 RM 2 16639 20248 18339 12642 14252 12540 17747 21351 3 17841 11943 18080 12 846 RM values are mean SD:.
significant relative to CONCLUSION These values before RM vorl frequently results indicate that all RM improved oxygenation immediately after the reaction in both groups in relation to the duration of its effect (15 min, 2 RM. cheaper in the group was A, while for w 3 RM ADIP these patients seems to be more effective 0633 elastic properties of lung tissue in experimental ARDS RECRUITS. A CT scan study S. Grasso, T. Stripoli, F. Staffieri D . Franchini, M. Sacchi, P. Pugliese, V. De Monte, V. Valentini, A. Crovace, T. Fiore Emergency and Organ Transplantation, University of Bari, Bari, Italy INTRODUCTION. States open-lung theory that maximizing are alveolar alveolar re recruitment of the tides minimize Ren hyperinflation.
However actelectasis ARDS areas of intense inflammatory reaction. We tested the hypothesis that the lung recruited areas have different elastic properties in that area, the internally ventilated normally have been ZEEP. METHODS. transpulmonary pressure constant (PTP, inflation distrettual the CT scan is the expression of elastance distrettual. In 21 pigs dam interred intravenous lung ( se administration of LPS, No. 7, the inhalation Hcl, No. 7, alveolar re, 7 and 5 healthy pigs, chest CT scan was depressurized end-tidal (ZEEP and w during a Man vers recruitment into the lung of a PTP receive 35 cmH2O. RESULTS Data are mean / standard deviation, p \ 0.01 damged compared to healthy lungs.
Table 1: healthy healthy lung damage ZEEP ZEEP LRM LRM expansion (% 1 2 84 4 01 10 7 ventilated normal (% 86 5 14 6 29 15 68 11 poorly ventilated (11% May 13 41 December 18 12 nonventilated (1 1% 11 30 17 4 3 CONCLUSION. CT D damping properties and thus ventilated the subject differed significantly from those elastances distrettual of healthy lung tissue from the same PTP. In addition, we have found a highly significant correlation (R 2 0.8779, p \ 0.001 Chen between Fl normally at ZEEP and tissue w during distension LRM ventilated suggesting that the fact that these areas with a high risk of hyperinflation, the alveolar are re recruiting independent dependent. thanksgiving GRANT. Universit t Bari . reduced PEEP OPTIMIZATION WITH TECHNICAL 0634 forced oscillation (OFT Sch the lung ventilation in a saline Maschinenw bottle at the ALI Associated PIGS Kostic1 P.
, PP Pompilio2, Olerud1 Andersson, E. Zannin2, G. Hedenstierna3, A. Pedotti2, PGM Frykholm1, R. Dellaca2 1Surgical Sciences, care to sthesiologie, Universit t Uppsala, Uppsala, Sweden, Tues 2Dipartimento Bioingegneria, Universit t Politecnico di Milano, Milan, Italy, 3 rztlicher Sciences, Clinical Physiology, University of t Uppsala, Uppsala, Sweden INTRODUCTION. atelectasis associated alveolar collapse is an h more often results in acute lung injury (ALI, leading to a ht shunt-erh and hypox chemistry. current treatment strategies aim to recruit alveoli. collapsed alveoli GE opened by a You Ver recruitment (RM tend to end without adequate PEEP (PEEP MR. followed by inadequate PEEP permits unstable alveoli recollapse. The resulting cyclic recruitment / derecruitment may need during the mechanical ventilation can be Lungensch ending ventilator-associated (VALI contribute, despite improved oxygenation. The results of animal studies suggest that a total of previous input reactance (Xrs measured by the forced oscillation tech-
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