, The optimal 
to decreased PaO2 400mmHg shock, and AZD2281 Olaparib ventilation was continued for 4 h selected Hlt. H Thermodynamics, respiratory mechanics and gas exchange were w During the entire experiment, and pulmonary histopathology Ver Changes in relative lung weight, dry / wet lung IL-6 expression (ELISAs were determined measured. RESULTS The heart rate (HR, mean arterial pressure (MAP, cardiac output (CO, central venous pressure (CVP and pulmonary capillary wedge pressure (PAWP did not differ between the four groups in the experiment (p [0.05. After lung recruitment sustained improvements were observed in oxygenation in all groups. Histologically significantly the lung injury score lower in the group 9 Hz HFOV than other groups (p \ 0.05.
Lung weight was wet / dry is not among the four groups (p [0.05. The expression of IL-6 in lung tissue significantly decreases 6Hz and 9Hz HFOV-treated animals differ (p \ 0.05. CONCLUSION. Compared with CMV and HFOV at low frequency, the h here HFOV results in less frequency Lungensch apology. high-frequency oscillation ventilation (HFOV may be a strategy of optimal lung protection. by Ventilation GDC-0449 0518 high frequency of the PERCUSSION on oxygenation in patients with acute respiratory failure Poriazi M., C. Routsi, E. Angelopoulos, D Zervakis, C Roussos, S Nanas intensive care unit, H Pital Evangelismos, Athens, Greece INTRODUCTION. high frequency ventilation drums (HFPV was used in the past, primarily as a salvage therapy in patients with acute respiratory failure and persistent hypox chemistry with promising results.
However, the R of the HFPV has not yet YOUR BIDDING by a relatively small number of supply best published data CONFIRMS. We tested the effectiveness of HFPV (VDR fan 4 HYPOX chemistry in patients with different etiology compared with ventilation classical mechanics. METHODS. We studied eight mechanically ventilated patients (APACHE II-20 June 10 3 SOFA score, lung injury score 2.4 0.8. oxygenation, h hemodynamic and respiratory parameters were monitored on conventional mechanical ventilation (ventilation controlled the loudness strength, VCV, w during a short period of 2 hours 30 minutes and Lich HFPV closing after reconnection Herk with conventional ventilation. RESULTS.
PO2/FiO2 values, pO2, pCO2, pH on ventilation mmliche mechanics, before beginning the HFPV after 2 hours and 30 minutes after the re-HFPV conjunction with conventional mechanical ventilation were using the method of repeated measurements (ANOVA analysis and a total of a significant effect. All p-values were Bonferroni adjusted. PO2/FiO2 HFPV before and after 2 hours significantly increased ht (128 versus 68 281 and 110 P0.02 . However, it has been 30 min after reconnection VCV reduced (202 81, p0.04. pH values, two hours agrees on, after HFPV to those before (7.47 compared. 7.37 vs 0.09 09 or 30 minutes after reconnection p0.01 changes VCV (7.42 0.09, p0.03. in PCO2 were also significantly different between VCV and HFPV (44.7 vs. 32.5 15.3mmHg and 5.7mmHg p0 .049, and 30min after reconnection to VCV 0th (39.07 6.7mmHg, p 01 changes to the PO2 was also before and after HFPV (91.
6 vs. 178.7 25.1mmHg and 66.1mmHg p0.01 and 30min reconnection to VCV (123.5 39.2, 0.03 p0 important. There were no statistically significant Ver changes in the H thermodynamics may need during the study period. CONCLUSION show. These results indicate that the short-term acute HFPV improved oxygenation without adversely caning of H thermodynamics. should focus further studies to L ngs effects HFPV as a different type of ventilation in patients with hypox chemistry. BIOMARKERS 0519 Lungensch the BEFORE AND AFTER THE INTRODUCTION of high-frequency ventilation for PERCUSSION smoke inhalation injury PAEG repertoire, K. Van Loey Department of Critical Care, H Pital K Queen Astrid, Brussels, Belgium. INTRODUCTION several biomarkers of Lungensch endings are: Pr predictors for morbidity t and mortality t in patients with acute lung injury (The ALI.
small volume of tidal ventilation lung protective strategy is associated with a significant decrease in plasma levels of biomarkers in relation to the strategy of high tidal volume ventilation. The main objective of this study was to determine whether the institution of ventilation high-frequency percussive ventilation in patients various serious injuries spontaneously from smoke inhalation rft pre Lungensch termination by measurements of biomarkers of Lungensch endings before and after the start HFPV. METHODS. a prospective observational cohort study was conducted in the burn intensive care unit. Zw lf intubated, mechanically ventilated patients with smoke inhalation were enrolled. physiological data and serum samples within 6 hours before intubation and in two ZEITR were Umen collected several may need during the first 24 hours after intubation, the concentration of interleukin (IL-6, IL-8 and TNF-alpha to measure. differences in biomarkers before and after intubation were
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