RESULTS Anti-HDV-IgM correlated with histological inflammatory (p< 0.01) as well as with biochemical disease activity (ALT and AST p<0.01) and is associated
with the stage of liver disease (p< 0.01). Before therapy, anti-HDV-IgM levels did not differ between patients responding to therapy and nonresponder patients. However, anti-HDV-IgM levels significantly declined from baseline to week 96 of therapy in virological responder patients whereas anti-HDV-IgM OD values remains unchanged or even increased in most of the nonresponders. Antibody declines became evident already during week 24 of therapy in responding patients (responder vs. nonresponder learn more W24 p=0.05; W48 p<0.01; W96 p=0.02). At week 24 ten out of 1 1 virological responders had an anti-HDV-IgM decline while this was only the case in five out of 1 1 nonresponders patients. CONCLUSIONS Anti-HDV-IgM testing is a cheap and reliable marker providing valuable additional information on disease activity in hepatitis delta. Moreover, anti-HDV-IgM testing could be used
as an on-treatment marker for response to individualize treatment and to avoid unnecessary exposure to PEG-IFNa. The value of this marker needs to be validated NVP-BGJ398 in vivo in larger studies. Disclosures: Cihan Yurdaydin – Advisory Committees or Review Panels: Janssen, Roche, Merck, Gilead Selim Gurel – Speaking and Teaching: Glead, BMS, Roche, MSD, Glead, BMS, Roche, MSD Stefan Zeuzem – Consulting: Abbvie, Achillion Pharmaceuticals, Boehringer Ingel-heim GmbH, Bristol-Myers Squibb Co., Gilead, Novartis Pharmaceuticals, Merck & Co., Idenix, Janssen, Roche Pharma AG, Vertex Pharmaceuticals, Presidio, Santaris, Inc George V. Papatheodoridis – Advisory Committees or Review Panels: Janssen, Abbott, Boehringer, Isotretinoin Novartis, BMS, Gilead, Roche; Consulting: Roche; Grant/Research Support: BMS, Gilead, Roche; Speaking and Teaching: Janssen,
Novartis, BMS, Gilead, Roche, MSD Kerstin Port – Speaking and Teaching: Roche Markus Cornberg – Advisory Committees or Review Panels: Merck (MSD Ger-mamny), Roche, Gilead, Novartis; Grant/Research Support: Merck (MSD Ger-mamny), Roche; Speaking and Teaching: Merck (MSD Germamny), Roche, Gilead, BMS, Novartis, Falk Michael P. Manns – Consulting: Roche, BMS, Gilead, Boehringer Ingelheim, Novartis, Idenix, Achillion, GSK, Merck/MSD, Janssen, Medgenics; Grant/Research Support: Merck/MSD, Roche, Gilead, Novartis, Boehringer Ingelheim, BMS; Speaking and Teaching: Merck/MSD, Roche, BMS, Gilead, Janssen, GSK, Novartis Heiner Wedemeyer – Advisory Committees or Review Panels: Transgene, MSD, Roche, Gilead, Abbott, BMS, Falk; Grant/Research Support: MSD, Novartis, Gilead, Roche, Abbott; Speaking and Teaching: BMS, MSD, Novartis, ITF The following people have nothing to disclose: Anika Wranke, Benjamin Heidrich, Stefanie Ernst, Armin Koch, Beatriz Calle Serrano, Florin A. Caruntu, Manuela G.
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