The result of comparison of PT and AFP are quite the opposite(P < 0.05).The level of PTA is lower in HEV co-infection in CHB, and the levels of GGT,T-BIL,D-BIL are lower in
HEV infection alone(0.05< P < 0.10).There are no obvious distinction with levels of AST,ALP,TP,ALB,GLB and I-BIL between the two groups. Among the 336 patients of HLC detected HEV serologically,there is a total of 18 patients combined positive anti-HEV IgM, which have 1 case of hepatic encephalopathy,3 cases of upper gastrointestinal hemorrhage,4 cases of liver failure and 2 cases of death in the group of HLC above.However, in 318 patients combined negative anti-HEV IgM, there are 5 cases of hepatic encephalopathy, 1 case of liver failure and no death among them.The levels of ALT ,ALP,T-BIL,D-BIL,I-BIL in group of positive anti-HEV IgM are significantly higher than the group of negative http://www.selleckchem.com/products/Romidepsin-FK228.html anti-HEV IgM .The levels of GLB in group of positive anti-HEV IgG are significantly higher than the group of negative anti-HEV IgG. And the level of A/G obviously lower than the group of negative anti-HEV IgG. Comparison of clinical data was BMN 673 in vitro made between 165 cases of HEV infection alone and 37 cases of co-infection with patients of HBV (19 cases of the 188 sporadic cases of acute
hepatitis E and 18 cases of HLC with positive anti-HEV IgM detected in this experiment.The age and the levels of PTA,ALT,ALP,GGT,ALB,CHE in group of HEV infection alone is significantly
higher than the group of HEV co-infection with patients of HBV. The level of PT is quite the opposite.Clinical data of 165 cases of HEV infection alone were compared with 24 cases of HLC with positive anti-HEV IgM (6 cases in 188 sporadic cases of acute hepatitis E and 18 cases of HBV- induced liver cirrhosis with positive anti-HEV IgM which detected in this experiment). Patients in group of HEV infection alone had higher levels of ALB,CHE than the group of HLC with positive anti-HEV IgM,and higher level of PTA(P < 0.05) .The level of AST in 13 cases of CHB with positive anti-HEV IgM is significantly higher than 24 cases of HLC with positive anti-HEV IgM (P < 0.05). Conclusion: Patients of viral hepatitis B may prior to earlier HEV than common human.Nowadays, there is a higher selleckchem incidence of HEV co-infection in patients with HBV-induced liver cirrhosis. HEV co-infection can obviously accentuate further disease. What’more, it may also has affect of accelerating the course of liver fibrosis. Patients in group of HEV co-infection with patients of HBV had worse liver function, oagulation function and higher incidence of liver failure and death.Patients with HLC infected by HEV had severe disease than patients with CHB or HEV infection alone.HEV co-infection should be pay more attention to patients of HBV.
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