There were no significant differences in GMC 2 weeks following th

There were no significant differences in GMC 2 weeks following the PPV-23 for any PCV-7 serotype between the 3 and 2 PCV-7 dose groups. GMC were significantly higher (each p < 0.001) 2 weeks following the PPV-23 compared with the pre-PPV-23 levels, for all PCV-7 serotypes in the group that had not received PCV-7 in infancy ( Table 1). Two weeks following the 12 month PPV-23, there was no significant difference Entinostat molecular weight between the 3 and 2 dose PCV-7 groups or between the 3 and

single dose groups in the proportion of children with antibody concentrations ≥0.35 and ≥1 μg/mL for the PCV-7 serotypes (Table 2). At 17 months of age the groups that had received the 12 month PPV-23 continued to have significantly higher GMC (each p < 0.001) for all PCV-7 serotypes compared to those that had not received the 12 month www.selleckchem.com/products/MDV3100.html PPV-23 but the same number of PCV-7 doses ( Table 3). The single PCV-7 dose group that received the PPV-23 continued to have higher GMC compared to the 2 or 3 dose PCV-7 groups which did or did not receive the PPV-23. There were significantly higher proportions with antibody concentrations ≥1 μg/mL for the PCV-7 serotypes in those groups that had received the 12 month PPV-23 compared with those that had not received the PPV-23 ( Table 3). Two weeks following the 12 month PPV-23, GMC and the proportions with antibody concentrations ≥0.35 and

≥1 μg/mL for all non-PCV-7 serotypes in the PPV-23 were significantly higher (each p < 0.001) than pre-PPV-23 levels ( Table 4). To

assess for non-specific effects, the proportion of children with antibody concentrations ≥0.35 μg/mL were compared between the 3, 2, and single PCV-7 dose groups with the group that had received no prior PCV-7. There were no significant differences in responses to the non-PCV-7 serotypes following the 12 month PPV-23 between the 3 and 0 PCV dose groups (data not shown). However for serotypes 15B and 19A, the proportion of children with antibody concentrations ≥0.35 μg/mL were significantly higher in the 2 and single dose groups compared with the 0 PCV dose group (data not shown). By 17 months of age, GMC and the proportion with antibody concentrations ≥0.35 μg/mL were still significantly higher (each p < 0.001) for all non-PCV-7 serotypes in the groups that had received very the PPV-23 vaccine at 12 months compared to the groups that had not ( Table 5). Following PPV-23 at 12 months of age, low grade fever was common (28.2%) while high grade fever occurred in 6.1%. The description of other general reactions is shown in Table 6. Local injection site reactions occurred in a minority of recipients. All events resolved within 48 h. There were 101 SAEs throughout the 2 year follow up period, with none attributable to receipt of any of the study vaccines. One child who had received 2 doses of PCV-7 at 6 and 14 weeks of age died at 9 months of age from dehydration secondary to acute gastroenteritis.

Related posts:

1. Nephrin expression remained suppressed even 12 weeks right after
2. Interaction was significant (p=0,00005) The arterio�Cvenous
3. 5-HT Receptor due to metabolic differences in the generation of active
4. No significant correlations were detected
5. Although increase in total cholesterol level became significant a