These
results suggest a close association between the MIP-1 alpha response and the Th1-type T-cell responses in chlamydial lung infections. Cellular & Molecular Immunology (2010) 7, 355-360; doi:10.1038/cmi.2010.32; published online 12 July 2010″
“Several causative genes have been identified for both dystonia-parkinsonism Angiogenesis inhibitor and neurodegeneration with brain iron accumulation (NBIA), yet many patients do not have mutations in any of the known genes. Mutations in the ATP13A2 lead to Kufor Rakeb disease, a form of autosomal recessive juvenile parkinsonism that also features oromandibular dystonia. More recently, evidence of iron deposition in the caudate and putamen have been reported in patients with ATP13A2 mutations. We set out to determine the frequency of ATP13A2 mutations in cohorts of idiopathic NBIA and dystonia-parkinsonism.
We screened for large deletions using whole genome arrays, and sequenced the entire coding PARP cancer region in 92 cases of NBIA and 76 cases of dystonia-parkinsonism. A number of coding and non-coding sequence variants were identified in a heterozygous state, but none were predicted to be pathogenic based on in silico analyses. Our results indicate that ATP13A2 mutations are a rare cause of both NBIA and dystonia-parkinsonism. (C) 2012 Elsevier Ireland Ltd. All rights reserved.”
“The effect of spatial heterogeneity in epidemic models has improved with computational advances, yet far less progress has been made in developing analytical tools selleckchem for understanding such systems. Here, we develop two classes of second-order moment closure methods for approximating the dynamics of a stochastic spatial model of the spread of foot and mouth disease. We consider
the performance of such ‘pseudo-spatial’ models as a function of R-0, the locality in disease transmission, farm distribution and geographically-targeted control when an arbitrary number of spatial kernels are incorporated. One advantage of mapping complex spatial models onto simpler deterministic approximations lies in the ability to potentially obtain a better analytical understanding of disease dynamics and the effects of control. We exploit this tractability by deriving analytical results in the invasion stages of an FMD outbreak, highlighting key principles underlying epidemic spread on contact networks and the effect of spatial correlations. (C) 2008 Elsevier Inc. All rights reserved.”
“We employ all-electron ab initio time-dependent density functional theory based method to calculate the long-range dipole-dipole dispersion coefficient, namely, the van der Waals (vdW) coefficient (C-6) between fullerenes and finite-length carbon nanotubes as well as between these structures and different small molecules.
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