This means that these cells feature a particular sensitivity for homogeneous stimulation of their receptive fields, but only when considering the spike count. Apparently, this characteristic sensitivity is not yet present when the very first spike is generated and Birinapant rather develops over the course of the response in a dynamic fashion. Further experiments showed that it relies
on inhibitory signaling in the retinal circuit (Bölinger and Gollisch, 2012). This also explains why the first-spike latency is not affected, as the inhibition needs an additional synaptic stage via an amacrine cell and is thus delayed compared to direct excitation Dabrafenib mouse (Werblin and Dowling, 1969, Roska et al., 2006 and Cafaro and Rieke, 2010). Spatial stimulus integration in these ganglion cells is thus a dynamic process, which endows these cells with particular sensitivity
to detect large objects, even at low contrast, as already discussed above. The finding of two different types of nonlinear spatial integration underscores the importance of quantitatively investigating stimulus integration rather than only assessing whether or not integration occurs in a linear fashion. The results also exemplify the power of the iso-response method for this task, as it allows separating spatial integration from subsequent cell-intrinsic nonlinearities. In the same way, the iso-response method had previously been used to elucidate Florfenicol spectral and temporal integration in insect auditory receptor
cells (Gollisch et al., 2002 and Gollisch and Herz, 2005) and has recently also been applied to understanding how neurons in primate visual cortex represent color information (Horwitz and Hass, 2012). Application of the iso-response method is most useful for directly testing the integration of few stimulus components. In the above example, the stimulus consisted of the contrast values in just two spatial regions; other examples have applied iso-response measurements with three stimulus components (Gollisch et al., 2002 and Horwitz and Hass, 2012). Beyond three stimulus components, both the high-dimensional search and the visual display of the results will become increasingly tricky. The strength of the iso-response method clearly rather lies in the fact that it can be applied with a limited, selected set of stimulus components to obtain details of their integration. In the example of Fig. 4, the selected stimulus components were relatively large parts of the receptive field center, thereby each combining the contributions of several presynaptic bipolar cells.
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