To our knowledge, no previous study has examined the separate rel

To our knowledge, no previous study has examined the separate relationships between 25(OH)D2, 25(OH)D3 and bone outcomes in childhood. Since 25(OH)D3 makes the major contribution to total 25(OH)D, it is relevant to compare our findings with those from these previous studies based on total 25(OH)D. In a prospective study of 171

girls aged 9–15 years, total 25(OH)D was positively associated with gains in femoral neck BMD over the following 3 years which may have reflected an influence of 25(OH)D3 on cortical thickness as we observed [16]. On the other hand, our findings contrast with those of a previous study in which total 25(OH)D was found to be positively related to BMDC of the radius and tibia in a cross-sectional study based on 193 10- to 12-year-old girls [15]. In terms of previous interventional studies, in a recent study in 20 pairs of peripubertal {Selleck Anti-diabetic Compound Library|Selleck Antidiabetic Compound Library|Selleck Anti-diabetic Compound Library|Selleck Antidiabetic Compound Library|Selleckchem Anti-diabetic Compound Library|Selleckchem Antidiabetic Compound Library|Selleckchem Anti-diabetic Compound Library|Selleckchem Antidiabetic Compound Library|Anti-diabetic Compound Library|Antidiabetic Compound Library|Anti-diabetic Compound Library|Antidiabetic Compound Library|Anti-diabetic Compound Library|Antidiabetic Compound Library|Anti-diabetic Compound Library|Antidiabetic Compound Library|Anti-diabetic Compound Library|Antidiabetic Compound Library|Anti-diabetic Compound Library|Antidiabetic Compound Library|Anti-diabetic Compound Library|Antidiabetic Compound Library|Anti-diabetic Compound Library|Antidiabetic Compound Library|Anti-diabetic Compound Library|Antidiabetic Compound Library|buy Anti-diabetic Compound Library|Anti-diabetic Compound Library ic50|Anti-diabetic Compound Library price|Anti-diabetic Compound Library cost|Anti-diabetic Compound Library solubility dmso|Anti-diabetic Compound Library purchase|Anti-diabetic Compound Library manufacturer|Anti-diabetic Compound Library research buy|Anti-diabetic Compound Library order|Anti-diabetic Compound Library mouse|Anti-diabetic Compound Library chemical structure|Anti-diabetic Compound Library mw|Anti-diabetic Compound Library molecular weight|Anti-diabetic Compound Library datasheet|Anti-diabetic Compound Library supplier|Anti-diabetic Compound Library in vitro|Anti-diabetic Compound Library cell line|Anti-diabetic Compound Library concentration|Anti-diabetic Compound Library nmr|Anti-diabetic Compound Library in vivo|Anti-diabetic Compound Library clinical trial|Anti-diabetic Compound Library cell assay|Anti-diabetic Compound Library screening|Anti-diabetic Compound Library high throughput|buy Antidiabetic Compound Library|Antidiabetic Compound Library ic50|Antidiabetic Compound Library price|Antidiabetic Compound Library cost|Antidiabetic Compound Library solubility dmso|Antidiabetic Compound Library purchase|Antidiabetic Compound Library manufacturer|Antidiabetic Compound Library research buy|Antidiabetic Compound Library order|Antidiabetic Compound Library chemical structure|Antidiabetic Compound Library datasheet|Antidiabetic Compound Library supplier|Antidiabetic Compound Library in vitro|Antidiabetic Compound Library cell line|Antidiabetic Compound Library concentration|Antidiabetic Compound Library clinical trial|Antidiabetic Compound Library cell assay|Antidiabetic Compound Library screening|Antidiabetic Compound Library high throughput|Anti-diabetic Compound high throughput screening| female twins, D3 supplements for 6 months led to an increase in tibial cortical bone area

due to reduced endosteal expansion as assessed by pQCT [7]. In contrast, in a recent D2 supplementation trial in 73 girls aged 12–14 years, no effect was observed on pQCT parametres [9]. Although these findings are consistent with our observation of an inverse association between endosteal adjusted for periosteal circumference and 25(OH)D3, but not 25(OH)D2, to our knowledge, BIX 1294 mouse no previous study has directly compared the effect of administering these two forms of vitamin D on cortical bone. In terms of biological explanations for possible distinct effects of 25(OH)D2 and 25(OH)D3 on bone, as suggested many by our results, indirect pathways via PTH may be involved. Whereas 25(OH)D3 levels are known to be inversely related to PTH, as confirmed here, an equivalent relationship

was not seen for 25(OH)D2, which is consistent with a previous finding that a large dose of D3 decreased PTH in the elderly, whereas D2 was without effect [29]. Any tendency for 25(OH)D2 and 25(OH)D3 to differ in respect of their relationships with PTH may be partly due to the fact that D2 is less potent than D3: D3 and its metabolites have a higher affinity than D2 for hepatic 25-hydroxylase and vitamin D receptors; D3 is not directly metabolised to 24(OH)D as is D2; 25(OH)D2 has a lower affinity for vitamin D binding protein compared to 25(OH)D3, leading to faster metabolism and a shorter half life [10]. However, adjusting our analyses for PTH did not attenuate the observed association between 25(OH)D3 and endosteal adjusted for periosteal circumference, suggesting that differing relationships with PTH are unlikely to explain the distinct associations between 25(OH)D2, 25(OH)D3 and cortical bone parametres which we observed.

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