Probiotics could

be a reasonable strategy in prevention o

Probiotics could

be a reasonable strategy in prevention of antibiotic associated disturbances of the intestinal homeostasis and disorders. buy GSK872 Acknowledgements We thank Manuela Kramp for technical assistance. This work was supported by grants from The Excellence Cluster “”Inflammation at Interfaces”" (funded by the German Research Foundation, DFG) and the Medical Faculty of the Christian-Albrechts-University (CAU) Kiel within the research program “”inflammation medicine”". References 1. Wistrom J, et al.: Frequency of antibiotic-associated diarrhoea in 2462 antibiotic-treated hospitalized patients: a prospective study. J Antimicrob Chemother 2001,47(1):43–50.PubMedCrossRef 2. McDonald LC, Owings M, Jernigan DB: Clostridium difficile infection in patients discharged from US short-stay hospitals, 1996–2003. Emerg Infect Dis 2006,12(3):409–415.PubMedCrossRef 3. Zilberberg MD, Tillotson GS, McDonald C: Clostridium difficile infections among hospitalized children, United States, 1997–2006. Emerg Infect Dis 2010,16(4):604–609.PubMed 4. Kelly CP, LaMont JT: Clostridium difficile-more difficult than ever. N Engl J Med 2008,359(18):1932–1940.PubMedCrossRef 5. Hickson M, et al.: Use of probiotic Lactobacillus preparation to prevent diarrhoea associated with antibiotics: randomised double blind placebo

controlled trial. BMJ 2007,335(7610):80.PubMedCrossRef 6. McFarland LV: Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease. Am J Gastroenterol 2006,101(4):812–822.PubMedCrossRef 7. McFarland LV: Evidence-based review of probiotics learn more for antibiotic-associated diarrhea and Clostridium difficile infections. Anaerobe 2009,15(6):274–280.PubMedCrossRef Cobimetinib cell line 8. Wenus C, et al.: Prevention of antibiotic-associated diarrhoea by a fermented probiotic milk drink. Eur J Clin Nutr 2008,62(2):299–301.PubMedCrossRef 9. Corr S, et al.: Bacteriocin production as a mechanism

for the antiinfective activity of Lactobacillus salivarius UCC118. Proc Natl Acad Sci USA 2007, 104:7617–7621.PubMedCrossRef 10. Ng S, et al.: Mechanisms of find more action of probiotics: recent advances. Inflamm Bowel Dis 2009,15(2):300–310.PubMedCrossRef 11. O’Hara A, Shanahan F: Mechanisms of action of probiotics in intestinal diseases. Scientific World Journal 2007, 7:31–46.PubMedCrossRef 12. Sakata T, et al.: Influences of probiotic bacteria on organic acid production by pig caecal bacteria in vitro. Proc Nutr Soc 2003, 62:73–80.PubMedCrossRef 13. Sakata T, et al.: Probiotic preparations dose-dependently increase net production rates of organic acids and decrease that of ammonia by pig cecal bacteria in batch culture. Dig Dis Sci 1999,44(7):1485–1493.PubMedCrossRef 14. Oelschlaeger TA: Mechanisms of probiotic actions – A review. Int J Med Microbiol 2010,300(1):57–62.PubMedCrossRef 15. Klein A, et al.

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