05 As depicted, if 5% of the controls experience delayed fluid

05. As depicted, if 5% of the controls experience delayed fluid … Assuming a median

survival of around 2 years in control population and ALI increases the risk of death by about 1.25, then the study has 80% power to reject the null hypothesis of equal survival of controls and ALI patients. A target of 100 ALI survivors and 100 controls assuming a standard deviation of the health related quality of life score among ICU patients of 10 units, the study has 80% power to detect a difference in self reported quality of life of 4.0 units or greater. Discussion The LIPS study is a population based observational cohort study that aims to identify patients at high risk Inhibitors,research,lifescience,medical of developing ALI early in the course of illness (at the time of hospital admission), and compare the in-hospital (second hit) exposures and outcomes of patients at high risk who do and do not develop ALI. Analysis and comparison of exposures and outcomes between patients at high risk Inhibitors,research,lifescience,medical identified before ALI development is essential to understand clinical pathogenesis of ALI and design effective prevention strategies.

By determining not only candidate interventions, but also the attributable burden of ALI, it will allow the prioritization of preventive strategies and future clinical trials. Olmsted County offers Inhibitors,research,lifescience,medical a unique opportunity to study

potential ALI prevention targets in a geographically things defined population because all the critically ill patients from the county are admitted to Mayo Clinic hospitals. The use of population based sample eliminates the referral bias common in clinical Inhibitors,research,lifescience,medical studies performed at tertiary care institutions[23]. As a part of study design we have developed a near real time Inhibitors,research,lifescience,medical access to pertinent data in electronic medical records to identify patients from the community with or at high risk of ALI. The electronic infrastructure will greatly facilitate to conduct this population based study by minimizing study coordinator time necessary to screen GSK-3 large number of patients. Time-sensitive biospecimen collection in a population of patients with strictly defined phenotype and detailed capture of environmental exposures will allow for the development of important biospecimen repository for future collaborations in Genome Wide Association and plasma biomarker studies. The principal limitation of our study is imposed by the broad nature and definition of the primary outcome of interest, ALI [21]. The exclusion of left atrial hypertension poses a particular challenge in the clinical assessment of ALI. In addition to using a standardized definition and extensive training of study personnel, all ALI cases will be reviewed by trained expert investigators.

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