Discussion Only a few studies have reported increased serum BNP l

Discussion Only a few studies have reported increased serum BNP levels in patients with head trauma [7–10].

Costa et al. reported that serum BNP levels did not increase in patients with head injury and it had no correlation with cerebral salt-wasting syndrome [12]. Kavalci et al. reported that serum BNP might be useful in evaluation of head trauma [13]. Cevik et al. selleck chemicals llc demonstrated that BNP levels exceeding 10 pg/ml were associated with an intracranial abnormality in patients with head injury [7]. Sviri et al. showed that serum BNP levels increased SP600125 solubility dmso immediately following head injury [8]. Similarly, Lu et al. reported that BNP levels increased in patients with head trauma [9]. Cevik et al. showed that serum BNP levels significantly differed between patients with and without head trauma [7]. In contrast, we did not detect any significant difference between the 2 groups. We believe that this resulted from a low patient number in Group 2. We suggest that further studies with larger sample size may establish a relationship between serum BNP and head trauma. Neither, Çevik et al. nor Kavalci et al. showed a significant correlation between trauma mechanism and serum BNP. We also found a similar result. BNP appears to be released Selleckchem GW 572016 into bloodstream in all kinds of head trauma. Çevik et al. reported a significant relevance between delay in admission and

BNP levels. They showed that a positive correlation exists between admission time and BNP levels [7]. Kavalci et al. showed that there was no significant correlation between the serum BNP levels and admission time [13]. Our results are support to Kavalci et al. GCS is commonly used for assessment of neurological status of head trauma patients. There is a general agreement on the predictive power of GCS in patients with mild and serious head trauma, although there are various approach considerations with respect to radiological evaluation of minor head trauma cases. Thus, studies aiming to establish the indications

of CT scanning of the head region or criteria for hospital admission by using some biochemical markers and clinical features [3–5]. Some reports suggested that the severity of head trauma and serum BNP levels are not significantly correlated [7, 10, 13]. Wu et al., in contrast, reported that serum BNP levels increased to a greater Neratinib mw extent in patients with more severe head trauma [11]. We found no significant correlation between head trauma severity and serum BNP levels. However, all of our patients with minor head trauma group. This subject should be further clarified with adequate studies. In a study by Çevik et al. serum BNP levels were significantly higher in patients with an intracranial lesion compared to those who did not. Cevik et al. proposed that serum BNP levels can be used as a surrogate marker of head trauma [7]. In contrast, Stewart et al. and Kavalci et al. suggested that this biomarker has no any appreciable value for this indication [10].

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